Why Is Molecular Hydrogen So Good For Us?

The Problem

Every single day we are exposed to the harmful effect of our environment. Pollution, sun exposure and various toxins from a broad range of sources damage our cells. Science is starting to understand the biology behind this damage. One of the main reasons is caused by the molecules known as ‘free radicals'. Typically, molecules have two electrons to keep them stable. The free radicals, however, only have one electron due to the harmful environmental impact, which makes them unstable and a contributing factor to the breakdown of our bodies.

Everyday we are exposed to cell-damaging free radicals.

The unstable free radical are always seeking to become stabilised by pulling in an additional electron from healthy molecules. This process sets off a chain reaction and more molecules become imbalanced and thus unhealthy. A damaging process known as oxidative stress. Persistent oxidative stress is one of the major causes of most lifestyle-related diseases, cancer and the ageing process.

The Solution

Antioxidants are substances that protect your cells from oxidative stress and inflammation by removing the harmful free radicals. The amount of free radicals in the body must be in balance to maintain a good health. Certain vitamins are known as antioxidants and are believed to counteract oxidative stress by reducing the formation of free radicals. Nevertheless, vitamins and nutrients are linked to a limited therapeutic success. On the other hand, molecular hydrogen has potential as a novel antioxidant in preventative and therapeutic applications.

Molecular Hydrogen eliminates free radicals.

Hydrogen readily gives up electrons to free radicals, which stabilizes them and stops them in their tracks. Hydrogen shows not only effects against oxidative stress, but also various anti-inflammatory and anti-allergic effects. Hydrogen holds advantages over other antioxidants because it is such a tiny molecule: it is able to penetrate cell membranes, and can easily enter deep into cell components, where other antioxidants are not able to reach. Also, hydrogen boosts the body’s defenses by increasing production of natural antioxidants. No adverse effects of consuming hydrogen exist.

 “It is not an overstatement to say that hydrogen’s impact on therapeutic and preventive medicine could be enormous in the future.”

Atsunori Nakao, MD, PhD

The Effect of Hydrogen

The action of hydrogen is diverse, but the main action is antioxidant behaviour. It has a strong erasing power of active oxygen and selectively erases the most atrocious "hydroxyl radical" of the free radical family. There is no substance that erases hydroxyl radicals more efficiently than hydrogen. Numerous effects besides antioxidant effects have been revealed in hydrogen. Moreover, hydrogen exhibit anti-inflammatory, anti-allergic, and anti-apoptotic properties at the sub-cellular level. Hydrogen is the smallest element in the world, and therefore permeable to penetrate any cell wall. Hydrogen is delivered to and acts on peripheral cells as well as within the cells. Molecular hydrogen has characteristics of a therapeutic drug with higher mobility and cellular bioavailability than any other anti-oxidants/vitamins/nutrients. It protects DNA, RNA and proteins from oxidative stress, which is one of the major causes of most lifestyle-related diseases, such as cancer, diabetes and the ageing process. It triggers the activation of the body's endogenous antioxidant self defence system (SOD, GSH, CAT) to improve the regulation redox homeostasis. Also, it hydrates and rejuvenates on the cellular level and is ideal to be administered in iv drip injection. Over 600 peer-reviewed articles demonstrate hydrogen to have therapeutic potential in essentially every organ of the human body and in 150 different human disease models.

Decrease in cell DNA damage as seen in 8-OHdG biomarker

Urinary 8-OHdG serves as a biomarker of oxidative stress and cell DNA damage. Increased levels of 8-OHdG contributes to carcinogenesis (cancer) and other lifestyle related diseases. Our products went through a clinical trial measuring 8-OHdG levels in 32 patients before and after administration of hydrogen in IV drip. In nearly all tested patients, a decrease in 8-OHdG was observed. Conclusion: Our products help reduce the speed of oxidative stress and DNA damage. Steady-state levels of DNA damages represent the balance between formation and repair. Average frequencies of steady state endogenous DNA damages in mammalian cells occurs at an average frequency of 2,400 per cell. When 8-OHdG is induced by a DNA damaging agent it is rapidly repaired. The contribution happens via two different mechanisms. The first mechanism involves modulation of gene expression, whereas the second is through the induction of mutations. Thus 8-OHdG, if not repaired, can directly cause frequent mutations, some of which may contribute to cancer.

Adaptation of Hydrogen Therapy

Health maintenance, prevention of diseases and aging are areas where hydrogen has successfully been adopted. Prevention of diseases such as cancer, dementia, slowing down the speed of aging or reduction of internal radiation exposure due to recent radioactive cancer therapy as well as fatigue recovery, muscle and tissue stiffness, coldness, rough skin, etc in particular. In intense sports, active oxygen, which is generated in large quantities, can threaten the athlete's health and recovery time. Especially professional athletes should adopt hydrogen therapy as a sports supplement due to its efficient breakdown of excessive active oxygen.

Cancer treatment with hydrogen

Cancer cells release active oxygen, damage the surrounding stroma, metastasize, and allow growth. Hydrogen eliminates active oxygen and suppresses proliferation and metastasis of cancer cells. Cancer cells get energy from anaerobic glycolysis without the use of the mitochondria. Hydrogen restores mitochondrial function in cancer cells and promotes apoptosis (suicide of cancer cells). In cancer treatment, in addition to antitumor effect by hydrogen therapy, it is effective also in reducing side effects caused by anticancer drugs.

Range of Disease Treatment

Lifestyle related diseases such as diabetes, hypertension, arteriosclerosis, hyperlipidemia.
Cardiovascular diseases such as thrombosis, stroke, cerebral infarction, myocardial infarction.
Allergic and immune diseases such as atopic dermatitis, cedar pollinosis, bronchial asthma, rheumatoid arthritis.
Dementia, Alzheimer's disease, Parkinson's disease and other neurological diseases.
Various cancer diseases such as lung cancer, colon cancer, breast cancer, pancreatic cancer, prostate cancer.
Liver disease such as hepatitis C, liver cirrhosis.
Pancreatic diseases such as intestinal diseases such as Crohn's disease and chronic pancreatitis.
Various respiratory diseases, neonatal/pediatric diseases, eye diseases, periodontal disease, cataract etc.


How Our Hydrogen Products Benefit Your Skin

The 4 key pillars underpinning Hycare Akarui's product range:

1. Anti-ageing properties to reduce the formation of fine lines and wrinkles.
2. Maintain smooth, plump and youthful appearance of skin.
3. Visually prolong your skin’s natural youth and radiance.
4. Optimising your skin’s health through hydrating benefits.

How Our Hydrogen Products Benefit The Rest Of Your Body

Powerful Antioxidant

Due to its extremely small size (0.24 Trillionth of a Meter), it can spread throughout the body in seconds and penetrate all tissue, cells, and cell components providing rapid protection from free radical damage.

Selective Antioxidant

Molecular hydrogen has special selective properties that allow it to deal with the “bad” free radicals but leave the good free radicals to do their jobs.

Holistic Antioxidant

Due to its molecular size, it can provide protection to the inside the cells and outside; external surface of the cell membrane (lipid-bi-layer), the extra-cellular matrix, plasma, and all external surfaces of cells, organs, and all tissue.

Anti-cancer Action

Promotes cancer cell death, suppression of cancer growth/metastasis.

Energy Production

Hydrogen becomes available to the mitochondria in our cells, which uses this to create ATP, the source of energy in our cells. Hydrogen also increases glycogen stores in the liver and may improve functioning of all organs in the body by increasing stores of available energy.

Cell Signalling

Cell signalling is a way the body can send a message to different parts of the body to supply it with required cells. Hydrogen has recently been found to act as a cell signalling molecule. Hydrogens antioxidant and anti-inflammation qualities come from this ability to carry signals for the body.

Negative Orp Effect

All Hycare Akarui products maintain a highly negative Oxidative Reduction Potential. As we age, we oxidise, like an old car that rusts. Things that oxidize have a positive ORP. Therefore if we want to slow down the aging process, it is a good idea to ingest things with a negative ORP.


Ageing is created by the body being broken down by free radicals. By having a continual supply of hydrogen, the body can use this to neutralise free radicals and slow down ageing.


Molecular hydrogen is 100% bio available, so it will act on all of the body’s organs.


Acts as a powerful anti-inflammatory in the body.

Fast Blood Transformation

Immediate difference measurable In just five minutes.

Enhanced Cellular Hydration

It has been shown to increase cellular hydration by enhancing the ability to move extracellular water into the cell.

Sports Recovery & Performance Enhancer

By increasing cellular hydration, reducing inflammation and most importantly reducing lactic acid by up to 18% this is a powerful sports performance and recovery enhancer.

Enables Production Of Bodies Own Antioxidants

Acts as a natural Nrf2 transcription factor activator that allows the body to make its own antioxidant enzymes (e.g., superoxide dismutase (SOD), catalase, and glutathione peroxidase).

Hydrogen Medicine And Clinical Trials

Many clinical trials have been carried out on the effects of hydrogen. Both on animals and humans. Here you can see a list of some of the most interesting study areas where hydrogen has been proven to have a positive effect. For more detailed info on molecular hydrogen studies we recommend the site www.molecularhydrogenstudies.com. Download our presentation “Clinical Use And Future Prospects” here: H2 presentation. It is based on clinical trials done with HyCare Akarui developed equipment. The trials have been done by our partner doctor, Dr Tsuji, who is running the worlds leading clinic for hydrogen treatments located in Tokyo, Japan: http://tsuji-c.jp/

Clinical trials successfully done on on humans

  • Ischema/reperfusion injuries: Cerebral infarction
  • Neuroprotection: Parkinsons disease
  • Inflammation: Rheumatoid arthritis
  • Kidney diseases: Hemodialysis, cystitis
  • Side effects from cancer therapy: Radiotherapy
  • Mitochondrial diseases
  • Exercise: Lactic acid, fatigue
  • Metabolic syndrome: Diabetes, hyperlipidermia, arteriosclerosis

Clinical trials on humans currently in progress

  • Ischema/reperfusion injuries: Myocardial infarction, organ transplantation, post-cardiac arrest
  • Neuprotection: Dementia
  • Metabolic syndrome: Fatty liver

Clinical trials done on animals

  • Neuroprotection: Depression, Anesthetia
  • Inflammation: Polymicrobial sepsis, wound healing, bowel disease
  • Ageing: Wrinkles, Freckles
  • Side effects from cancer therapy: Chemotherapy
  • Metabolic syndrome: Hypertension, obesity

Clinic Menu Example

Most clinics HyCare Akarui work with offer treatments such as “intravenous saline hydrogen solution administration” or “local injection hydrogen water/saline administration” or ” hydrogen gas inhalation”.  We can provide all the equipment to start these therapies.

Hydrogen Infusion

Hydrogen Infusion

A basic infusion with hydrogen dissolved in 100 ml saline solution. Hydrogen molecules and hydrogen ions are administered directly into the body to exert a direct effect.

Infusion of Hydrogen + Vitamins

An intravenous drip containing hydrogen, vitamin B group, vitamin C etc in 100 ml saline solution.

Hydrogen + Myers Cocktail drip

An intravenous drip made with Myers Cocktail on a hydrogen basis.

Hydrogen + LipoGlu drip

A trioxic drip with antioxidant power, hydrogen, α-lipoic acid and glutathione content.

Super Hydrogen Infusion

A  drip consisting of hydrogen vitamin infusion and hydrogen LipoGlu infusion.

Local Hydrogen Injection

Intra-muscular Injection

Injections into muscles such as neck, shoulders, waist. Suppress inflammation, analgesic action and blood circulation improving action.

Intra-articular Injection

Injections to joints such as shoulder, elbow, knee.

Molecular Hydrogen FAQ

What is an Antioxidant?

Molecules that interact with free radicals terminating potentially harmful chain reactions before vital molecules are damaged. Recent studies show that molecular hydrogen is a unique and effective antioxidant that neutralizes the dangerous hydroxyl radical without interfering with other free radicals required by the human body.

What is a Free Radical?

Free radicals are atoms or groups of atoms with an odd (unpaired) number of electrons which can be formed when oxygen interacts with certain molecules. Once formed these highly reactive radicals can start a chain reaction, like dominoes. Their chief danger comes from the damage they can do when they react with important cellular components such as DNA, or the cell membrane. Cells may function poorly or die if this occurs. To prevent free radical damage the body has a defense system of antioxidants.

What is Cell Signalling?

Cell Signalling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Errors in cellular information processing are responsible for diseases such as cancerautoimmunity, and diabetes.

What is ROS (Reactive Oxygen Species)?

ROS are chemically reactive molecules containing oxygen. Examples include peroxidessuperoxideshydroxyl radicals, and singlet oxygen. They are formed as a natural byproduct of the normal metabolism of oxygen and play important roles in cell signalling and homeostasis.

What is Reduction?

Reduction is the chemical reaction that results in the GAIN of electrons by a molecule, atom, or ion. Antioxidants reduce free radicals by donating an electron to the radical which then ceased to a be radical.

What is Molecular Hydrogen?

Molecular Hydrogen, commonly written H2, is a molecule formed by bonding two hydrogen atoms which share their electrons. Numerous scientific studies in recent years have shown that molecular hydrogen is believed to be beneficial in more than 150 human diseases.

What is Homeostasis?

Homeostasis is a property of a system in which variables are regulated so that internal conditions remain stable and relatively constant despite the influences of external events. An example of a homeostatic system would be the buffering properties of the body to maintain the blood pH of 7.35-7.45.

What is Oxidation?

Oxidation is the chemical reaction that results in the LOSS of electrons by a molecule, atom, or ion. Oxidation doesn’t have to have anything to do with oxygen. An oxidation reaction may produce free radicals, leading to chain reactions that may damage cells.

What is Oxidative Stress?

Oxidative Stress occurs during times of environmental stress (heat exposure for example) where ROS levels can increase dramatically which may result in significant damage to cell structure